Products
TRIM63 antibody
Category:
Research Area:
Synonyms: | FLJ32380 antibody, IRF antibody, Iris RING finger protein antibody, MuRF 1 antibody, MURF1 antibody, MURF2 antibody, RING finger protein 28 antibody, RNF28 antibody, SMRZ antibody, TRIM63 antibody, tripartite motif containing 63 antibody | ||
Catalogue No.: | FNab08992 | Reactivity: | Human, Mouse, Rat |
Host: | Rabbit | Tested Application: | ELISA, WB, IHC, IF |
Clonality: | polyclonal | Isotype: | IgG |
- SPECIFICATIONS
- Product Name
- TRIM63 antibody
- Catalogue No.
- FNab08992
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tripartite motif-containing 63
- Alternative Names
- FLJ32380 antibody, IRF antibody, Iris RING finger protein antibody, MuRF 1 antibody, MURF1 antibody, MURF2 antibody, RING finger protein 28 antibody, RNF28 antibody, SMRZ antibody, TRIM63 antibody, tripartite motif containing 63 antibody
- UniProt ID
- Q969Q1
- Observed MW
- 40 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab08992(TRIM63 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human heart using FNab08992(TRIM63 antibody) at dilution of 1:50
Immunofluorescent analysis of HeLa cells using FNab08992 (TRIM63 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Background
- E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.